How can I permanently turn on my Microsoft Security Essentials and get rid of spyware and adware?

MSE is a darn good anti virus program but is a bit weak when it comes to malware. The best thing going today for malware is Malwarebytes. a href="http://www.malwarebytes.org" rel="nofollow"http://www.malwarebytes.org/a Download it, allow it to update its definitions and then run a full system scan. Always do security scans in Safe Mode with System Restore turned off. After the scan, you can turn System Restore back on and it will create a new Restore Point that is clean of viruses and malware. To make sure that MSE is on and running in the background, open the program by click on its icon in the tray. When the program opens, click the Settings tab and then click "Real-time protection in the left panel and choose the settings that you want.